Modelling the potential role of engineered symbiotic bacteria in malaria control

主题:Modelling the potential role of engineered symbiotic bacteria in malaria control
主要内容:A recent experimental study suggests that the engineered symbiotic bacteria Serratia AS1 may provide a novel, effective and sustainable biocontrol of malaria. These recombinant bacteria have been shown to be able to rapidly disseminate throughout mosquito populations and to efficiently inhibit development of malaria parasites in mosquitoes in controlled laboratory experiments. In this talk, I will report a recent work in which we develop a climate-based malaria model which involves both vertical and horizontal transmissions of the engineered Serratia AS1 bacteria in mosquito population. We show that the dynamics of the model system is totally determined by the vector reproduction ratio $R_v$, and the basic reproduction ratio $R_0$. If $R_v \le 1$, then the mosquito-free state is globally attractive. If $R_v>1$ and $R_0\le 1$, then the disease-free periodic solution is globally attractive. If $R_v>1$ and $R_0>1$, then the positive periodic solution is globally attractive. Numerically, we verify the obtained analytic result and evaluate the effects of releasing the engineered Serratia AS1 bacteria in field by conducting a case study for Douala, Cameroon. We find that ideally, by using Serratia AS1 alone, it takes at least 25 years to eliminate malaria from Douala. This implies that continued long term investment is needed in the fight against malaria and confirms the necessity of integrating multiple control measures.
专家姓名:Zou Xingfu
工作单位:加拿大西安大略大学
专长和学术成就:研究兴趣为微分方程和动力系统的理论及应用,特别是反应扩散方程、常泛函微分方程及偏泛函微分方程及其在生物领域的应用
专家简介:邹幸福教授分别在中山大学,湖南大学和约克大学(York University, Canada)获得学士,硕士和博士学位,并在维多利亚大学(University of Victoria, Canada)和佐治亚理工(Georgia Institute of Technology, USA) 从事过博士后研究工作。曾任教于加拿大纽芬兰纪念大学(Memorial University of Newfoundland, Canada), 现为加拿大西安大略大学(University of Western Ontario)应用数学系的教授。
时间:2021-01-05 10:00:00
地点:线上

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